Classic papers and C. elegans history

Research papers:

The genetics of Caenorhabditis elegans. Brenner S. Genetics. 1974 May;77(1):71-94.

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Sulston JE, Horvitz HR. Dev Biol. 1977 Mar;56(1):110-56.

The embryonic cell lineage of the nematode Caenorhabditis elegans. Sulston JE, Schierenberg E, White JG, Thomson JN. Dev Biol. 1983 Nov;100(1):64-119.

The structure of the nervous system of the nematode Caenorhabditis elegans. White JG, Southgate E, Thomson JN, Brenner S. Phil. Trans. Royal Soc. London. Series B, Biol Scien. Vol.314, Issue 1165 (Nov 12, 1986), 1-340


C. elegans history:

The beginning of connectomics: a commentary on White et al. (1986) ‘The structure of the nervous system of the nematode Caenorhabditis elegans’  Emmons SW, Phil. Trans. Royal Soc. London. Series B 370: 1-11 March 2014

In the Beginning Was the Worm . . . Sydney Brenner, Genetics 182: 413–415 June 2009

The natural history of C.elegans research. Ankeny RA. Nat Rev Genet. 2001 Jun;2(6):474-9.

Of Worms and Programmes: Caenorhabditis Elegans and the Study of Development. Soraya de Chadarevian, Stud. Hist. Phil. Biol. & Biomed. Sci., Vol. 29, No. 1, pp. 81–105, 1998

An interview with Sydney Brenner

The art and design of genetic screens: caenorhabditis elegans. Jorgensen EM, Mango SE. Nat Rev Genet. 2002 May;3(5):356-69.

Super models. Maureen M. Barr, Physiol Genomics 13: 15–24, 2003

On the shoulders of worms Rhiannon Macrae, Trends in Genetics November 2014


History of neurons:

Ramón y Cajal: a century after the publication of his masterpiece. Pedro J. Andres-Barquin, Endeavour Vol. 25(1) 2001

A historical reflection of the contributions of Cajal and Golgi to the foundations of neuroscience. De Carlos JA, Borrell J. , Brain Res Rev. 2007 Aug;55(1):8-16.

Cajal, Golgi, Nansen, Schafer and the Neuron Doctrine. Ortwin Bock, Endeavour Vol. 37 No. 4

Cajal and the discovery of a new artistic world: The neuronal forest. Javier DeFelipe, Progress in Brain Research, Volume 203 2013

The death of Cajal and the end of scientific romanticism and individualism. Javier DeFelipe, Eduardo Garrido, and Henry Markram, Trends in Neurosciences, October 2014, Vol. 37, No. 10

Cajal’s debt to Golgi. Edward G. Jones, Brain Research Reviews 66 (2010) 83–91

A unifying concept: the history of cell theory. Paolo Mazzarello, Nature Cell Biology Vol 1 May 1999

The neuron doctrine, the mind, and the artic.  Fodstad H, Kondziolka D, & Lotbiniere A. Neurosurgery 2001 Dec 47(6):1381-1389.


General information on C. elegans:

C. elegans outside the Petri dish. Frezal L and Felix M. eLIFE. 2015 Mar 4:e05849.



Sydney Brenner’s Loose Ends column for Current Biology 1994-2000